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Good Oral Health Linked to Improved Survival in Head & Neck Cancer
FRIDAY, Sept. 22, 2023 -- For patients with head and neck squamous cell carcinoma, good oral health is associated with improved survival, according to a study published online Sept. 19 in the Journal of the National Cancer Institute.
Jason Tasoulas,...
Source: Drugs.com - Pharma News - September 22, 2023 Category: Pharmaceuticals Source Type: news
PET/MR Imaging in Head and Neck Cancer
Head and neck squamous cell carcinoma (HNSCC) can either be examined with hybrid PET/MR imaging systems or sequentially, using PET/CT and MR imaging. Regardless of the acquisition technique, the superiority of MR imaging compared to CT lies in its potential to interrogate tumor and surrounding tissues with different sequences, including perfusion and diffusion. For this reason, PET/MR imaging is preferable for the detection and assessment of locoregional residual/recurrent HNSCC after therapy. In addition, MR imaging interpretation is facilitated when combined with PET. Nevertheless, distant metastases and distant second p...
Source: Magnetic Resonance Imaging Clinics of North America - September 22, 2023 Category: Radiology Authors: Minerva Becker, Claudio de Vito, Nicolas Dulguerov, Habib Zaidi Source Type: research
Skin and gut microbial associations with squamous cell carcinoma in solid organ transplant recipients
AbstractSolid organ transplant recipients (SOTRs) are burdened with a significantly higher risk of squamous cell carcinoma (SCC) compared to the general population. Accumulating evidence suggests the potential influence of microbial dysbiosis on transplant outcomes. Based on these observations, we sought to identify differences in the cutaneous and gut microbiomes of SOTRs with and without a history of SCC. This case –control study collected and analyzed non-lesional skin and fecal samples of 20 SOTRs > 18 years old with either ≥ 4 diagnoses of SCC since most recent transplant (n = 10) or 0 diagnoses o...
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
Posaconazole and risk of cutaneous squamous cell carcinoma after lung transplantation: a single institution, retrospective cohort study
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma
This study is an initial demonstration that the combination of PAC-1 and entrectinib may warrant further clinical investigation. Clinical trial registration: Clinical Trials.gov: NCT04589832.PMID:37738028 | DOI:10.1097/CMR.0000000000000927
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Matthew W Boudreau Emily J Tonogai Claire P Schane Min X Xi James H Fischer Jayanthi Vijayakumar Yan Ji Theodore M Tarasow Timothy M Fan Paul J Hergenrother Arkadiusz Z Dudek Source Type: research
Cancers, Vol. 15, Pages 4685: Role of DNA Methylation Profiles as Potential Biomarkers and Novel Therapeutic Targets in Head and Neck Cancer
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is associated with high mortality. The main reasons for treatment failure are a low rate of early diagnosis, high relapse rates, and distant metastasis with poor outcomes. These are largely due to a lack of diagnostic, prognostic, and predictive biomarkers in HNSCC. DNA methylation has been demonstrated to play an important role in the pathogenesis of HNSCC, and recent studies have also valued DNA methylation as a potential biomarker in HNSCC. This review summarizes the current knowledge on DNA methylation profiles in HPV-posi...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Kyunghee Burkitt Tags: Review Source Type: research
Conformal 3D computed tomography planned endoluminal brachytherapy for the local control of esophageal cancer
To outline the toxicity, tolerability, and efficacy of a 3D conformal computed tomography planned endoluminal brachytherapy (ELBT) treatment for esophageal adenocarcinoma (OAC) or squamous cell carcinoma (OSCC).
Source: Brachytherapy - September 22, 2023 Category: Cancer & Oncology Authors: Christopher M. Jones, Annabel Lyles, Peter Bownes, Rebecca Goody, Mohan Hingorani, Eldho Joseph, Ganesh Radhakrishna Source Type: research
Estimating Remaining Life Expectancy in Veterans with Basal Cell Carcinoma Using an Automated Electronic Health Record Scoring System: A Retrospective Cohort Study
Active surveillance may be considered for low-risk basal cell carcinomas (BCC) in patients with limited life expectancy; however, estimates of life expectancy are not readily available. Veterans Health Administration ’s (VHA) Care Assessment Need (CAN) score may address this problem.
Source: Journal of the American Academy of Dermatology - September 22, 2023 Category: Dermatology Authors: Matthew P. Dizon, Eleni Linos, Susan M. Swetter Source Type: research
Increased vitamin B12 levels in patients with oral cancer
Conclusion: Our study found increased vitamin B12 levels in OC patients, and it was statistically significant.
Source: Indian Journal of Dental Research - September 22, 2023 Category: Dentistry Authors: Prashant Gupta Subhash Chandra Awanindra Kumar Jha Tanya Khaitan Anjani Kumar Shukla Shantala R Naik Source Type: research
Serum autoantibody profiling of oral squamous cell carcinoma patients reveals NUBP2 as a potential diagnostic marker
In conclusion, the differential serum autoantibodies identified in the current study, including those for NUBP2, could be used as potential biomarkers for early diagnosis or as screening biomarkers for OSCC pending investigation in a larger cohort.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma
ConclusionPostoperative serum SCC and CEA levels predict the overall survival of ESCC surgical patients. More importance should be attached to the use of these markers in clinical applications.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
A novel near-infrared EGFR targeting probe for metastatic lymph node imaging in preclinical mouse models
For the treatment of patients with oral squamous cell carcinoma (OSCC), the imaging of cervical lymph nodes and the evaluation of metastastic progression are of great significance. In recent years, the develop...
Source: Journal of Nanobiotechnology - September 22, 2023 Category: Nanotechnology Authors: Diya Xie, Yunlong Li, Jiahong Shi, Yao Ping Zhu, Yiqing Wang, Christopher J. Butch and Zhiyong Wang Tags: Research Source Type: research
The Effects of Human Papillomavirus Status and Treatment on the Positive Predictive Value of Post-radiotherapy 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Advanced Head and Neck Squamous Cell Carcinoma
The high negative predictive value of post-chemoradiation (CRT) positron emission tomography-computed tomography (PET-CT) is well established in head and neck squamous cell cancers (HNSCC). The positive predictive value (PPV) remains under scrutiny, with increasing evidence that it is affected by several factors. The aim of this study was to assess the PPV of post-treatment PET-CT for residual nodal disease when stratified by treatment modality and tumour human papillomavirus (HPV) status.
Source: Clinical Oncology - September 22, 2023 Category: Radiology Authors: S. Zhou, C. Chan, Y.C. Lau, R. Rulach, H. Dyab, F. Hendry, C. Wilson, S. Schipani, C. Lamb, D. Grose, A. James, C. Maxfield, M.-F. Dempsey, C. Paterson Tags: Original Article Source Type: research
